Publications Frederik Deroose

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  • In Vivo Inhibition of RIPK2 Kinase Alleviates Inflammatory Disease
    By Tigno-Aranjuez, Justine T.; Benderitter, Pascal; Rombouts, Frederik; Deroose, Frederik; Bai, XiaoDong; Mattioli, Benedetta; Cominelli, Fabio; Pizarro, Theresa T.; Hoflack, Jan; Abbott, Derek W.
    From Journal of Biological Chemistry (2014), 289(43), 29651-29664.  Language: English,  Database: CAPLUS,
    DOI:10.1074/jbc.M114.591388
  • Synthesis of 2-aryl-3-hydroxymethyl-5,5-difluoropiperidines
    By Moens, Matthias; Verniest, Guido; De Schrijver, Matthias; ten Holte, Peter; Thuring, Jan-Willem; Deroose, Frederik; De Kimpe, Norbert
    From Tetrahedron (2012), 68(45), 9284-9288.  Language: English,  Database: CAPLUS, DOI:10.1016/j.tet.2012.08.049
  • Synthesis of gem-difluorinated 1,6-naphthyridine-5,7-diones
    By Piron, Karel; Kenis, Sara; Verniest, Guido; Surmont, Riccardo; Thuring, Jan Willem; ten Holte, Peter; Deroose,Frederik; De Kimpe, Norbert
    From Tetrahedron (2012), 68(34), 6941-6947.  Language: English,  Database: CAPLUS, DOI:10.1016/j.tet.2012.05.122
  • Synthesis of 3-amino-4-fluoropyrazoles
    By Surmont, Riccardo; Verniest, Guido; De Schrijver, Mathias; Thuring, Jan Willem; ten Holte, Peter; Deroose, Frederik; De Kimpe, Norbert
    From Journal of Organic Chemistry (2011), 76(10), 4105-4111.  Language: English,  Database: CAPLUS,
    DOI:10.1021/jo2000989
  • Synthesis of 5-amino- and 5-hydroxy-3,3-difluoropiperidines
    By Surmont, Riccardo; Verniest, Guido; Thuring, Jan Willem; ten Holte, Peter; Deroose, Frederik; De Kimpe, Norbert
    From Organic & Biomolecular Chemistry (2010), 8(20), 4514-4517.  Language: English,  Database: CAPLUS,
    DOI:10.1039/c0ob00231c
  • Preparation of piperazinecarboxamidines as antimicrobials
    By Meerpoel, Lieven; Freyne, Eddy; Deroose, Frederik; Coesemans, Erwin; Fernandez, Joaquin Pastor; Van Gestel, Jef; Francois, Isabelle; Thevissen, Karin; Cammue, Bruno
    From PCT Int. Appl. (2010), WO 2010068296 A1 20100617,  Language: English,  Database: CAPLUS
  • Synthesis of aminomethylated 4-fluoropiperidines and 3-fluoropyrrolidines
    By Verniest, Guido; Piron, Karel; Van Hende, Eva; Thuring, Jan Willem; Macdonald, Gregor; Deroose, Frederik; De Kimpe, Norbert
    From Organic & Biomolecular Chemistry (2010), 8(11), 2509-2512. Language: English, Database: CAPLUS,
    DOI:10.1039/c003380d
  • Synthesis of 4-Substituted 3,3-Difluoropiperidines
    By Surmont, Riccardo; Verniest, Guido; Thuring, Jan Willem; MacDonald, Gregor; Deroose, Frederik; De Kimpe, Norbert
    From Journal of Organic Chemistry (2010), 75(3), 929-932. Language: English, Database: CAPLUS,
    DOI:10.1021/jo902164z
  • Synthesis and biological evaluation of bridged analogues of the platelet aggregation inhibitor trifenagrel
    By Slusarczyk, Magdalena; de Borggraeve, Wim M.; Hoornaert, Georges; Robeyns, Koen; van Meervelt, Luc; Wu, Tongfei; Deroose, Frederik; Linders, Joannes T. M.
    From Letters in Drug Design & Discovery (2009), 6(7), 478-486. Language: English, Database: CAPLUS,
    DOI:10.2174/157018009789108213
  • Design and Synthesis of a Series of Piperazine-1-carboxamidine Derivatives with Antifungal Activity Resulting from Accumulation of Endogenous Reactive Oxygen Species
    By Francois, Isabelle E.; Thevissen, Karin; Pellens, Klaartje; Meert, Els M.; Heeres, Jan; Freyne, Eddy; Coesemans, Erwin; Viellevoye, Marcel; Deroose, Frederik; Martinez Gonzalez, Sonia; et al
    From ChemMedChem (2009), 4(10), 1714-1721. Language: English, Database: CAPLUS,
    DOI:10.1002/cmdc.200900249
  • Efficient synthesis of 3-alkoxy-4,4-difluoropiperidines
    By Surmont, Riccardo; Verniest, Guido; De Weweire, Arvid; Thuring, Jan Willem; MacDonald, Gregor; Deroose, Frederik; De Kimpe, Norbert
    From Synlett (2009), (12), 1933-1936. Language: English, Database: CAPLUS, DOI:10.1055/s-0029-1217533
  • Synthesis of 3-aminomethyl-3-fluoropiperidines
    By Van Hende, Eva; Verniest, Guido; Thuring, Jan-Willem; MacDonald, Gregor; Deroose, Frederik; De Kimpe, Norbert
    From Synlett (2009), (11), 1765-1768. Language: English, Database: CAPLUS, DOI:10.1055/s-0029-1217360
  • Synthesis of 1-Boc-3-fluoroazetidine-3-carboxylic acid
    By Van Hende, Eva; Verniest, Guido; Deroose, Frederik; Thuring, Jan-Willem; Macdonald, Gregor; De Kimpe, Norbert
    From Journal of Organic Chemistry (2009), 74(5), 2250-2253. Language: English, Database: CAPLUS,
    DOI:10.1021/jo802791r
  • New synthesis of 3-fluoropyrroles
    By Surmont, Riccardo; Verniest, Guido; Colpaert, Filip; Macdonald, Gregor; Thuring, Jan Willem; Deroose, Frederik; De Kimpe, Norbert
    From Journal of Organic Chemistry (2009), 74(3), 1377-1380. Language: English, Database: CAPLUS,
    DOI:10.1021/jo802272n
  • New Entries toward 3,3-Difluoropiperidines
    By Verniest, Guido; Surmont, Riccardo; Hende, Eva Van; Deweweire, Arvid; Deroose, Frederik; Thuring, Jan Willem; De Kimpe, Norbert
    From Journal of Organic Chemistry (2008), 73(14), 5458-5461. Language: English, Database: CAPLUS,
    DOI:10.1021/jo800768q
  • Synthesis and biological evaluation of methylene-bridged analogs of the potent cannabinoid receptor antagonist rimonabant
    By Slusarczyk, Magdalena; De Borggraeve, Wim M.; Hoornaert, Georges; Deroose, Frederik; Linders, Joannes T. M.
    From European Journal of Organic Chemistry (2008), (8), 1350-1357. Language: English, Database: CAPLUS,
    DOI:10.1002/ejoc.200700960
  • Synthesis and biological evaluation of 1,2,4-triazinylphenylalkylthiazolecarboxylic acid esters as cytokine-inhibiting antedrugs with strong bronchodilating effects in an animal model of asthma
    By Freyne, Eddy J.; Lacrampe, Jean F.; Deroose, Frederik; Boeckx, Gustaaf M.; Willems, Marc; Embrechts, Werner; Coesemans, Erwin; Willems, Johan J.; Fortin, Jerome M.; Ligney, Yannick; et al
    From Journal of Medicinal Chemistry (2005), 48(6), 2167-2175. Language: English, Database: CAPLUS,
    DOI:10.1021/jm049479m
  • Synthesis and biological evaluation of imidazol-2-one and 2-cyanoiminoimidazole derivatives: novel series of PDE4 inhibitors
    By Andres, J. Ignacio; Alonso, Jose M.; Diaz, Adolfo; Fernandez, Javier; Iturrino, Laura; Martinez, Pedro; Matesanz, Encarna; Freyne, Eddy J.; Deroose, Frederik; Boeckx, Gustaaf; et al
    From Bioorganic & Medicinal Chemistry Letters (2002), 12(4), 653-658. Language: English, Database: CAPLUS,
    DOI:10.1016/S0960-894X(01)00817-4
  • Preparation of 6-azauracil derivatives as interleukin-5 inhibitors
    By Lacrampe, Jean Fernand Armand; Freyne, Eddy Jean Edgard; Deroose, Frederik Dirk; Fortin, Jerome Michel Claude; Coesemans, Erwin
    From PCT Int. Appl. (2001), WO 2001010866 A1 20010215, Language: English, Database: CAPLUS
  • Identification of R146225 as a novel, orally active inhibitor of interleukin-5 biosynthesis
    By Van Wauwe, Jean; Aerts, Frans; Cools, Marina; Deroose, Frederik; Freyne, Eddy; Goossens, Jan; Hermans, Bart; Lacrampe, Jean; Van Genechten, Heidi; Van Gerven, Frans; et al
    From Journal of Pharmacology and Experimental Therapeutics (2000), 295(2), 655-661. Language: English, Database: CAPLUS
  • Preparation of IL-5 inhibiting 6-azauracil derivatives
    By Freyne, Eddy Jean Edgard; Deroose, Frederik Dirk; Lacrampe, Jean Fernand Armand; Embrechts, Werner Constant Johan; Fortin, Jerome Michel Claude
    From PCT Int. Appl. (2000), WO 2000037451 A1 20000629, Language: English, Database: CAPLUS
  • Preparation of IL-5 inhibiting 6-azauracil derivatives
    By Freyne, Eddy Jean Edgard; Deroose, Frederik Dirk; Petit, Davy Petrus Franciscus Maria; Lacrampe, Jean Fernand Armand
    From PCT Int. Appl. (2000), WO 2000031054 A1 20000602, Language: English, Database: CAPLUS
  • Preparation of IL-5 inhibiting 6-azauracil derivatives
    By Lacrampe, Jean Fernand Armand; Ligny, Yannick; Freyne, Eddy Jean Edgard; Deroose, Frederik Dirk
    From PCT Int. Appl. (2000), WO 2000031053 A1 20000602, Language: English, Database: CAPLUS
  • Preparation of novel 4,5-dihydroisoxazole derivatives and their use as pharmaceuticals for T cell-mediated diseases
    By Freyne, Eddy Jean Edgard; Andres-Gil, Jose Ignacio; Deroose, Frederik Dirk; Petit, Davy Petrus Franciscus Maria; Matesanz-Ballesteros, Maria Encarnacion; Alvarez Escobar, Rosa Maria
    From PCT Int. Appl. (2000), WO 2000021959 A1 20000420, Language: English, Database: CAPLUS
  • Preparation of interleukin-5 inhibiting 6-azauracil derivatives
    By Freyne, Eddy Jean Edgard; Lacrampe, Jean Fernand Armand; Deroose, Frederik Dirk; Venet, Marc Gaston
    From Eur. Pat. Appl. (2000), EP 987265 A1 20000322, Language: English, Database: CAPLUS
  • A General and Highly Efficient Solid Phase Synthesis of Oligosaccharides. Total Synthesis of a Heptasaccharide Phytoalexin Elicitor (HPE)
    By Nicolaou, K. C.; Winssinger, Nicolas; Pastor, Joaquin; DeRoose, Frederik
    From Journal of the American Chemical Society (1997), 119(2), 449-450. Language: English, Database: CAPLUS,
    DOI:10.1021/JA963482G
  • Novel Enantioselective Syntheses of (+)-Biotin
    By Deroose, Frederik D.; De Clercq, Pierre J.
    From Journal of Organic Chemistry (1995), 60(2), 321-30. Language: English, Database: CAPLUS,
    DOI:10.1021/jo00107a009
  • A novel enantioselective synthesis of (+)-biotin
    By Deroose, Frederik D.; De Clercq, Pierre J.
    From Tetrahedron Letters (1994), 35(16), 2615-18. Language: English, Database: CAPLUS,
    DOI:10.1016/S0040- 4039(00)77187-5
  • A novel enantioselective synthesis of (+)-biotin
    By Deroose, Frederik D.; De Clercq, Pierre J.
    From Tetrahedron Letters (1993), 34(27), 4365-8. Language: English, Database: CAPLUS,
    DOI:10.1016/S0040-4039(00)79354-3
  • In vivo inhibition of RIPK2 kinase alleviates inflammatory disease
    By Tigno-Aranjuez Justine T; Mattioli Benedetta; Pizarro Theresa T; Abbott Derek W; Benderitter Pascal; Hoflack Jan; Rombouts Frederik; Deroose Frederik; Bai XiaoDong; Cominelli Fabio
    From The Journal of biological chemistry (2014), 289(43), 29651-64, Language: English, Database: MEDLINE
  • Synthesis of 3-amino-4-fluoropyrazoles
    By Surmont Riccardo; Verniest Guido; De Schrijver Mathias; Thuring Jan Willem; ten Holte Peter; Deroose Frederik; De Kimpe Norbert
    From The Journal of organic chemistry (2011), 76(10), 4105-11, Language: English, Database: MEDLINE
  • Synthesis of 5-amino- and 5-hydroxy-3,3-difluoropiperidines
    By Surmont Riccardo; Verniest Guido; Thuring Jan Willem; Ten Holte Peter; Deroose Frederik; De Kimpe Norbert
    From Organic & biomolecular chemistry (2010), 8(20), 4514-7, Language: English, Database: MEDLINE
  • Synthesis of 1-Boc-3-fluoroazetidine-3-carboxylic acid
    By Van Hende Eva; Verniest Guido; Deroose Frederik; Thuring Jan-Willem; Macdonald Gregor; De Kimpe Norbert
    From The Journal of organic chemistry (2009), 74(5), 2250-3, Language: English, Database: MEDLINE
  • Synthesis of aminomethylated 4-fluoropiperidines and 3-fluoropyrrolidines
    By Verniest Guido; Piron Karel; Van Hende Eva; Thuring Jan Willem; Macdonald Gregor; Deroose Frederik; De Kimpe Norbert
    From Organic & biomolecular chemistry (2010), 8(11), 2509-12, Language: English, Database: MEDLINE
  • Synthesis of 4-substituted 3,3-difluoropiperidines
    By Surmont Riccardo; Verniest Guido; Thuring Jan Willem; Macdonald Gregor; Deroose Frederik; De Kimpe Norbert
    From The Journal of organic chemistry (2010), 75(3), 929-32, Language: English, Database: MEDLINE
  • Design and synthesis of a series of piperazine-1-carboxamidine derivatives with antifungal activity resulting from accumulation of endogenous reactive oxygen species
    By Francois Isabelle E; Thevissen Karin; Pellens Klaartje; Meert Els M; Heeres Jan; Freyne Eddy; Coesemans Erwin; Viellevoye Marcel; Deroose Frederik; Martinez Gonzalez Sonia; et al
    From ChemMedChem (2009), 4(10), 1714-21, Language: English, Database: MEDLINE
  • New synthesis of 3-fluoropyrroles
    By Surmont Riccardo; Verniest Guido; Colpaert Filip; Macdonald Gregor; Thuring Jan Willem; Deroose Frederik; De Kimpe Norbert
    From The Journal of organic chemistry (2009), 74(3), 1377-80, Language: English, Database: MEDLINE
  • New entries toward 3,3-difluoropiperidines
    By Verniest Guido; Surmont Riccardo; Van Hende Eva; Deweweire Arvid; Deroose Frederik; Thuring Jan Willem; De Kimpe Norbert
    From The Journal of organic chemistry (2008), 73(14), 5458-61, Language: English, Database: MEDLINE
  • Synthesis and biological evaluation of 1,2,4-triazinylphenylalkylthiazolecarboxylic acid esters as cytokine-inhibiting antedrugs with strong bronchodilating effects in an animal model of asthma
    By Freyne Eddy J; Lacrampe Jean F; Deroose Frederik; Boeckx Gustaaf M; Willems Marc; Embrechts Werner; Coesemans Erwin; Willems Johan J; Fortin Jerome M; Ligney Yannick; et al
    From Journal of medicinal chemistry (2005), 48(6), 2167-75, Language: English, Database: MEDLINE
  • Synthesis and biological evaluation of imidazol-2-one and 2-cyanoiminoimidazole derivatives: novel series of PDE4 inhibitors
    By Andres J Ignacio; Alonso Jose M; Diaz Adolfo; Fernandez Javier; Iturrino Laura; Martinez Pedro; Matesanz Encarna; Freyne Eddy J; Deroose Frederik; Boeckx Gustaaf; et al
    From Bioorganic & medicinal chemistry letters (2002), 12(4), 653-8, Language: English, Database: MEDLINE
  • Identification of R146225 as a novel, orally active inhibitor of interleukin-5 biosynthesis
    By Van Wauwe J; Aerts F; Cools M; Deroose F; Freyne E; Goossens J; Hermans B; Lacrampe J; Van Genechten H; Van Gerven F; et al
    From The Journal of pharmacology and experimental therapeutics (2000), 295(2), 655-61, Language: English, Database: MEDLINE

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