Compound optimization

Targeted compound design can be applicable during compound optimization

  • Building strong SAR and SPR
  • Enhancing physicochemical properties of compounds (solubility, Log D, pKa)
  • Improving pharmacokinetic properties of compounds (absorption, clearance) to obtain most appropriate systemic exposure (either low or high)
  • Rationale for solving issues such as CYP interaction, hERG inhibition, blood-brain-barrier crossing, low metabolic stability (clearance), low plasma stability, low lung retention, etc.
  • If applicable, designing compounds as locally acting such as soft drugs (f.i. for occular, intestinal, pulmonary, skin deseases)
  • Possible advise on inactive excepients which could be used for in vitro and/or in vivo studies

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