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Asclepia Medchem Solutions

Medicinal chemistry

Medicinal chemistry consultancy and project management

pharmaceutical drugs. Medicinal chemistry involves the identification, synthesis, and development of new chemical entities suitable for therapeutic use. It is a highly interdisciplinary science combining organic chemistry with biochemistry, computational chemistry, pharmacology, molecular biology, statistics, and physical chemistry.

Asclepia MedChem Solutions is specialized in; 

  • Design and synthesis of novel compounds within all phases of drug discovery, hit generation, hit-to-lead, lead optimization towards clinical candidate

  • Optimizing (multiple) parameter(s) of new and existing compounds (activity, selectivity, physchem/eADME/eTox properties, in vivo properties)

  • Designing novel compounds, both ligand and target based

  • Definition of a high-level project Core Concept Profile (CCP)

  • Definition of a detailed research & development plan adapted to the project requirements (considering the intended field of application)

  • Definition of Target Product Profile (TPP) and Target Clinical Profile (TCP)

  • Defining and implementation of the most efficient project workflow

  • Performing in silico studies (modeling, in silico parameter analysis)

  • Designing necessary in vivo models (pharmacokinetic, PK linearity, Maximum Tolerated Dose, pharmacokinetic/pharmacodynamic, toxicity studies)

  • Performing benchmark studies (comparing new compound profiles to the profiles of known treatment)

  • Identifying and interacting with Key Opinion Leaders (KOLs)

  • Performing SWOT analysis of projects or within projects of compound (series)

Patent support

  • Performing patentability analysis of new and existing compound series

  • Analyzing the freedom-to-operate around compounds and compound series

  • Defining the best (overall) IP strategy

  • Writing patent applications

Grant applications

  • Identification of different grant possibilities (local, Europe, worldwide)

  • Direct interaction with the grant authorities

  • Writing and follow-up of different grant applications

Competitive landscape analysis

Competitive landscape analysis is an analysis that identifies projects from direct or indirect competitors to help comprehend the mission, vision, core values, niche market, strengths, and weaknesses and to compare vis-à-vis internal projects.

  • Performing an in-depth analysis of the competitive landscape for a specific indication, compound class or target class

Literature surveys

  • Doing detailed literature surveys on topics such as compound series, target classes, disease areas etc.

Due diligence

  • Performing due diligence as a third party to evaluate the potential of projects, chemical series, targets, etc…